报告题目：Patient-Specific MRI-Based 3D FSI Anisotropic Multi-Layer RV/LV/Patch Models for Pulmonary Valve Replacement Surgery Optimization
报告时间：2020年5月10日（周日）上午8:30—9:10
报 告 人：Dalin Tang教授
报告地点：Zoom云会议（ID：932 1144 3567, 密码：nanxinda60）
报告摘要：A patient-specific right/left ventricle and patch (RV/LV/Patch) combination model with fluid-structure interactions (FSI) was introduced to evaluate and optimize human pulmonary valve replacement/insertion (PVR) surgical procedure and patch design. Cardiac Magnetic Resonance (CMR) imaging studies were performed to acquire ventricle geometry, flow velocity and flow rate for healthy volunteers and patients needing RV remodeling and PVR before and after scheduled surgeries. CMR-based RV/LV/Patch FSI models were constructed to perform mechanical analysis and provide accurate assessment for RV mechanical conditions and cardiac function. These models include a) fluid-structure interactions, b) isotropic and anisotropic material properties, c) two-layer construction with myocardial fiber orientation, and d) active contraction. Both pre- and post-operation CMR data were used to adjust and validate the model so that predicted RV volumes reached good agreement with CMR measurements (error < 2%). two rv/lv/patch models were made based on pre-operation data to evaluate and compare two pvr surgical procedures: i) conventional patch with little or no scar tissue trimming; ii) small patch with aggressive scar trimming and rv volume reduction. our modeling results indicated that: a) patient-specific cmr-based computational modeling can provide accurate assessment of rv cardiac functions; b) pvr with a smaller patch and more aggressive scar removal led to reduced stress/strain conditions in the patch area and may lead to improved recovery of rv functions. more patient studies are needed to validate our findings.
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数学与统计学院
2020年5月7日
附：专家简介
Dalin Tang received his Ph.D from University of Wisconsin-Madison in 1988. He has been a faculty member at Worcester Polytechnic Institute since 1988 and is now a Professor of Mathematics and Biomedical Engineering. He was named John E. Sinclair Professor of Mathematics in 2003-2006. He received WPI Trustee’s award for Outstanding Research and Creative Scholarship in 2010, the highest honor for faculty research at WPI. He was elected Fellow of American Heart Association in 2011, Fellow of ASME 2016. He became a member of US National Academy of Inventers in 2016. He has been conducting research for cardiovascular modeling in the past 30 years and has made various contributions, especially in using image-based modeling for human ventricles and vulnerable plaque progression and rupture investigations. He serves as Editor-in-Chief for Molecular and Cellular Biomechanics, academic editor for PLOS One, and an editorial board member for BioMedical Engineering OnLine.
